However, the role of DHODH in mediating the effects of HDC on inhibiting ferroptosis and improving HF was somewhat influenced by GPX4 and FSP1, or its effects were overshadowed by those of GPX4 and FSP1, particularly in inhibiting iron accumulation, improving mitochondrial membrane potential, reducing myocardial fibrosis, and improving LVEF. The gene discussed is DHODH; the disease is Myocardial fibrosis.