Although there are some links between Rab GTPases and the stemness status of cancer cells (Brunel et al. 2021), RAB35, RAB21 and RAB5A proteins have been shown to promote cell migration by altering the recycling of β1 integrins leading to cancer metastasis (Pellinen et al. 2006, Argenzio et al. 2014). Here, RAB5A is linked to cancer.