Six gene hits appeared in kidney as well as prostate cancers (Table 1)—IL27, ZWINT, LY96, LAT, IGLL5, and AKAP5. The final hits, namely the 73 genes from the optimal Rabome, can be further explored for patterns in their mRNA deregulation and the possible malfunctioning of their encoded proteins, leading to cancer metastasis. This evidence concerns the gene IGLL5 and prostate carcinoma.