EVE combined with PI3K inhibitors (PI3Ki) exerted synergistic effects on cell and colony survival in rat GH3 and human GH-PAs cell lines, which may be attributed to the fact that PI3Ki enhanced the anti-tumor effect of EVE by modulating the PI3K/Akt/mTOR and MAPK pathways (108). This evidence concerns the gene PIK3CA and neoplasm.