In a study involving 53 PAs, growth hormone-secreting pituitary adenomas (GH-PAs) (10/14, 71%) and non-functional pituitary adenomas (NFPAs) (11/33, 33%) showed a significant association with the mTOR pathway, compared to the control group (1/5, 20%) (91). The gene discussed is GH1; the disease is pituitary gland adenoma.