By regulating the expressions and activities of various cellular targets such as BCL-2, cyclin D, PDGF, YAP, and IL6, at least 15 ncRNAs can regulate the activities of apoptotic and oncogenic WNT/β-catenin, TGF-β/SMAD4, EMT, interleukin, and YAP-associated pathways in liposarcoma to modulate cellular growth and metastases. This evidence concerns the gene SMAD4 and liposarcoma.