FOXO1 and autoimmune uveitis: Apremilast (a phosphodiesterase-4 inhibitor) was found to regulate Th17 and Treg cells by inhibiting the phosphorylation of the PI3K/Akt/Forkhead Box O1 (FoxO1) signaling pathway, thereby alleviating experimental autoimmune uveitis (EAU) [132].