HMOX1 and Alzheimer disease: In Alzheimer’s disease mice, cangrelor may reverse Aβ1−42-induced cognition deficits by inhibiting oxidative stress, neuroinflammation, and synaptic dysfunction mediated by nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) and NF-κB signaling [174].