ITGB4 and breast cancer: Moreover, unbiased transcriptomic analysis of NDRG1-CRISPR cells compared to control cells revealed an under-representation of genes involved in the extracellular matrix organization pathway including integrin-β4 (ITGB4) and ADAM metallopeptidase domain 12 (ADAM12) that are associated with BC cell migration and invasion and poor prognosis in patients with TNBC [28, 29].