On the other hand, evidence from autopsy and in vivo studies suggests that, compared to their male counterparts, older women show higher tau burden [18–20], particularly in the context of elevated Aβ levels [21], as well as worse tau-dependent cognitive impairment and faster rates of tau-dependent cognitive decline [22, 23], and increased risk of developing AD dementia at younger ages in APOE ε4 carriers [24]. Here, MAPT is linked to Cognitive impairment.