Other than care for IBD, the most frequent (mean number of visits > 2.00 per patient) reasons for primary care visits among patients with active disease were mental health, measurement of C-reactive protein, and smoking cessation, irrespective of diagnosis; general rheumatology in patients with UC and CD; psoriasis in patients with UC; and depression and anxiety in those with IBD (Appendix Table A3). This evidence concerns the gene CRP and major depressive disorder.