At higher radiation doses (12 Gy and 18 Gy), TREX1 is sufficient to scavenge cytoplasmic dsDNA accumulated in some cancer cells, thus preventing excessive activation of the cGAS-STING pathway and inhibiting the downstream interferon (IFN-I) responses (Cai et al. 2014; Vanpouille-Box et al. 2017). Here, TREX1 is linked to cancer.