Moreover, after HA@CD36i‐TR@siSCD1 treatment, we observed that in both LFD‐fed and HFD‐fed mice, the intratumoral CD8+/CD4+ T‐cell ratios increased significantly, with decreased Treg cells and increased TNF‐α and IFN‐γ levels, indicating that PCa transformed from a “cold” tumor to a “hot” tumor (Figure 6). Here, CD8A is linked to posterior cortical atrophy.