Moreover, HA@CD36i‐TR@siSCD1 had a potent immune‐enhancing effect, increasing the proportion of CD8+ T cells, decreasing the number of CD4+FoxP3+ Treg cells, promoting the release of the tumor killer factors TNF‐α and IFN‐γ, and transforming refractory PCa from “cold” tumors to “hot” tumors. Here, CD4 is linked to posterior cortical atrophy.