Moreover, HA@CD36i‐TR@siSCD1 had a potent immune‐enhancing effect, increasing the proportion of CD8+ T cells, decreasing the number of CD4+FoxP3+ Treg cells, promoting the release of the tumor killer factors TNF‐α and IFN‐γ, and transforming refractory PCa from “cold” tumors to “hot” tumors. Here, CD4 is linked to neoplasm.