Specifically, in this model of solid HNC, the improved therapeutic effect of the tLNPs compared to isoLNPs can be explained by several mechanisms: higher LNP retention and greater increased accumulation, or the synergism of knocking out SOX2 and inhibiting EGFR activation and its downstream signaling which subsequently suppresses the self‐renewal of cancer stem‐like cells modulation of SOX2‐oncogene. This evidence concerns the gene EGFR and cancer.