For this end, mice bearing UMSCC‐mCherry tumors were IT injected when the tumors had reached a volume of ≈50 mm3, at days 10, 17, and 23 post‐tumor inoculation, with 1 mg kg−1 of either sgSOX2‐αEGFR‐tLNPs (T‐sgSOX2), sgSOX2‐iso‐LNPs (I‐SOX2), sgNC‐αEGFR‐tLNPs (T‐sgNC), or sgNC‐iso‐LNPs (I‐sgNC) (Figure 6D, 10 mice/group). Here, SOX2 is linked to neoplasm.