Significantly increased expression of circadian genes was also reported in patients with nonsegmental vitiligo, with increased detection of Basic Helix-Loop-Helix ARNT Like 1 (BMAL1) and its polymorphic variants (single-nucleotide polymorphismn T/C vs T/T genotypes) [128], whose product is a clock transcription factor protein that generates circadian rhythms in physiological functions. The gene discussed is BMAL1; the disease is vitiligo.