Inhibition of NF-kB activation and islet β-cell inflammation can reduce proteinuria, stabilize glomerular basement membrane podocytes, and reduce glomerulosclerosis and renal inflammationSCFA reduction leads to inhibition of intestinal histone deacetylation, weakens histone post-translational modification, and promotes and participates in EMT of renal tubular epithelial cells. Here, NFKB1 is linked to glomerulosclerosis.