Inflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-18, and tumor necrosis factor-α (TNF-α), can be synthesized by different renal cells that plays a role in increasing the permeability of vascular endothelial cells, promoting the induction and differentiation of inflammatory cells, and activating apoptosis, thus promoting the development of DKD (25). The gene discussed is TNF; the disease is diabetic kidney disease.