IL6 and diabetic kidney disease: Inflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-18, and tumor necrosis factor-α (TNF-α), can be synthesized by different renal cells that plays a role in increasing the permeability of vascular endothelial cells, promoting the induction and differentiation of inflammatory cells, and activating apoptosis, thus promoting the development of DKD (25).