After adjusting for covariates such as gender, age, ethnicity, diabetes, mechanical ventilation use, CHF, COPD, MAP, AMI, pneumonia, rhythm, β-blocker use, SOFA score, BUN, albumin, Hct, and ALT, a trend of increasing 28-day ICU mortality with rising HR/T ratios was observed. This evidence concerns the gene ALB and chronic obstructive pulmonary disease.