It is well known that Notch1 plays a significant role in cardiac injury repair (108), and melatonin enhances Notch1/Hes1/Akt signaling in a receptor-dependent manner, rescuing the intracellular thioredoxin (Trx) system, reducing infarct size, cardiomyocyte apoptosis, and oxidative stress, thereby improving myocardial ischemia–reperfusion injury (109). This evidence concerns the gene NOTCH1 and myocardial ischemia.