TXN and myocardial ischemia: It is well known that Notch1 plays a significant role in cardiac injury repair (108), and melatonin enhances Notch1/Hes1/Akt signaling in a receptor-dependent manner, rescuing the intracellular thioredoxin (Trx) system, reducing infarct size, cardiomyocyte apoptosis, and oxidative stress, thereby improving myocardial ischemia–reperfusion injury (109).