By analyzing data from the TCGA and GTEx repositories, we assessed the transcriptome sequencing profiles of HNRNPC across multiple cancer types, offering insights into its Pan-cancer expression profiling indicated a notable overexpression of HNRNPC in 20 out of 26 prevalent malignancies including breast cancer (BRCA), Liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD) (Fig. 1A). This evidence concerns the gene HNRNPC and cancer.