For instance, in LUAD, Colon Adenocarcinoma (COAD), READ, KICH, Adrenocortical Carcinoma (ACC), and Stomach Adenocarcinoma (STAD), HNRNPC levels demonstrated a notable association with TMB, while among LIHC, Small Cell Esophageal Cancer (STES), READ, Uterine Corpus Endometrial Carcinoma (UCEC), Uveal Melanoma (UVM), Uterine Carcinosarcoma (UCS), Sarcoma (SARC), STAD, and Cholangiocarcinoma (CHOL), HNRNPC expression exhibited a direct positive association with MSI. The gene discussed is HNRNPC; the disease is endometrial carcinoma.