EGFR and malignant colon neoplasm: Another interesting example can be seen in Rezaei Adriani et al.’s study, where OMVs were engineered with scFv proteins to target EGFR on various cell lines in vitro, such as HT29 colorectal cancer cells, HCT-116 colon cancer cells, A-549 lung cancer cells, 4T1 breast cancer cells, and normal kidney HEK-293 cells; and in 4T1 mouse models in vivo.