EGFR and colonic neoplasm: Additionally, the use of bacteria as DDSs was further employed by Asensio-Calavia et al., where synthetic biology was utilized to program bacteria to target epidermal growth factor receptor (EGFR) on cancer cells and inject catalytic fragments of adenosine diphosphate-ribosyltransferase toxins into colon cancer HCT-116 cell line in vitro and in vivo, leading to cancer cell death and enhanced tumor suppression [154].