Interestingly, Lee et al. also reported that expression of ERCC1 in SCLC is lower compared to studies of tissue from NSCLC, suggesting that the greater biological aggressiveness of SCLC could be related to the loss of ERCC1 gene, which leads to impaired DNA-repair functions of the NER pathway [33]. This evidence concerns the gene ERCC1 and non-small cell lung carcinoma.