ERCC2 and lung cancer: In detail, Xu et al. indicated that individuals carrying at least one wild-type allele in ERCC1 rs11615 have a reduced risk of lung cancer development [12], while a large meta-analysis by Zhan et al., including 22 studies about ERCC2 rs13181 and rs1799793 polymorphisms suggested that mutant genotypes of these SNPs are correlated with lung cancer development [50].