GLP1R and diabetes mellitus: Therefore, combining the modulation of gut microbiota with other established treatments for Diabetes Mellitus (DM), including lifestyle adjustments, medications such as metformin, sodium-glucose co-transporter-2 inhibitors (SGLT2i), GLP-1 receptor agonists, and lipid-lowering drugs like statins, yields improved metabolic parameters, ultimately alleviating the damage brought about by this complex pathophysiology (10).