The susceptibility to pheochromocytoma can be linked to germline pathogenic variants in the RET proto-oncogene and tumor suppressor genes such as von Hippel-Lindau (VHL), and Neurofibromatosis type 1 (NF1) (2, 38, 39). This evidence concerns the gene NF1 and hereditary pheochromocytoma-paraganglioma.