IVW analysis revealed significant associations between 10 hub genes and the risk of PCOS: CD93 [P= 0.004; OR 95%CI= 1.150 (1.046, 1.264)], CYBB [P= 0.013; OR 95%CI= 1.650 (1.113,2.447)], DOCK8 [P= 0.048; OR 95%CI= 1.223 (1.002,1.494)], IRF1 [P= 0.036; OR 95%CI= 1.343 (1.020,1.769)], MBOAT1 [P= 0.033; OR 95%CI= 1.140 (1.011,1.285)], MYO1F [P= 0.012; OR 95%CI= 1.325 (1.065,1.649)], NLRP1 [P= 0.020; OR 95%CI= 1.143 (1.021,1.280)], NOD2 [P= 0.002; OR 95%CI= 1.139 (1.049,1.237)], PIK3R1 [P= 0.040; OR 95%CI= 1.241 (1.010,1.526)], PTER [P= 0.015; OR 95%CI= 0.923 (0.866,0.984)]. Here, IRF1 is linked to polycystic ovary syndrome.