CD4 and obesity due to melanocortin 4 receptor deficiency: Age ≥ 40 years (adjusted odd ratio (AOR) = 3.86; 95% confidence interval (CI): 1.08–13.73; and p=0.037), cluster of differentiation 4 (CD4) T-cell counts ≥ 500 cells/mm3 (AOR = 2.95; 95% CI: 1.01–8.59; and p=0.029), and insufficient physical activity (AOR = 4.6; 95% CI: 1.53–13.84; and p=0.007) were predictors of overweight and obesity.