CREB1 and lymphoma: In detail, following the confirmation that CLP36 was highly expressed in lymphoma cells, it was additionally observed that CLP36 silencing could lead to the suppression on the proliferation and metastasis potential of lymphoma cells and the enhancement on the apoptosis, which indirectly demonstrated that CLP36 may be associated with targeting the PI3K/AKT/CREB pathway (Fig. 6).