CLP36 (PDLIM1) is an actin-associated scaffold as a target hit and localizes to a variety of actin cytoskeletal elements, which is diffusely expressed in gastrointestinal tract, muscle, heart tissues and serves a cell-cell adhesion and focal adhesion modulator with functional importance in cancer (Dhanda et al., 2021; Chen et al., 2016). This evidence concerns the gene PDLIM1 and cancer.