Despite the success of LKB1-AMPK agonists, LKB1 inactivation also increase the median overall survival for some tumor types.194, 195, 196, 197, 198, 199, 200, 201, 202, 203 Given that LKB1 activity up-regulates stress response pathways and ROS scavenging in tumor cells, LKB1 deficient tumors are more susceptible to metabolic stressors. Here, STK11 is linked to neoplasm.