STK11 and colonic neoplasm: In fact, mouse models have linked LKB1 inactivation to cancers of the liver,102 bladder,103 prostate,104etc. In support of these findings, activating the LKB1-AMPK axis attenuates epithelial–mesenchymal transition and/or metastasis in renal cell carcinoma,105 hepatocellular carcinoma,106 and cancer of the colon,107 breast,108,109 and lung.110