In addition to pancreatic cancer, LKB1 somatic mutations, structural variants, amplifications, and deletions have been described in many cancer types including lung adenocarcinoma,36 hepatocellular carcinoma,37 head and neck squamous cell carcinoma38 as well as cancers of the colon,39 cervix,4 and breast40 (Fig. 1).41 This evidence concerns the gene STK11 and hepatocellular carcinoma.