Tissue-specific Cre-Lox LKB1 murine knockout models have identified many pathologies driven by mutational inactivation of LKB1 including cardiac defects,78 metabolic disorders,79 cachexia,80 kidney disease,81 hormonal imbalances,82 and tumorigenesis2,83, 84, 85 (Table 1). The gene discussed is STK11; the disease is kidney disorder.