Autoimmune regulator (Aire)-overexpressing dendritic cells (DCs) delayed T1DM processing by reducing CD4+ IFN-γ+ T cells level and enhancing CD73, lymphocyte activation Gene-3 (LAG-3), and folic acid receptor 4 (FR4) expression and CD4+ T cells apoptosis in splenocytes in STZ-T1DM mouse (18). This evidence concerns the gene AIRE and type 1 diabetes mellitus.