Before the follow-up experiment, we performed orbital CT examination on 3 female patients in the TAO group, and the analysis results showed that according to the imaging classification criteria, these 3 patients belonged to the type of muscle hyperplasia as the main manifestation, and all of them were at rest.We verified the expression of differentially expressed FRGs (ACO1, MMD, and HCAR1) in orbital adipose tissue of TAO patients and healthy controls by RT-PCR (Figures 9A, C), and the results showed that the expressions of ACO1 and HCAR1 in the TAO group were significantly down-regulated. This evidence concerns the gene ACO1 and thromboangiitis obliterans.