Additionally, IL-27 has been implicated in cutaneous inflammation and pruritus, as it can upregulate the transcription of protease-activated receptor 2 in the skin, which in turn enhances neural fiber density, elevates the expression of nerve growth factor and endothelin-1, intensifies hypersensitivity reactions, and potentiates the responsiveness of dorsal root ganglion cells to non-histaminergic pruritogens, thereby inducing skin inflammation and itching. Here, EDN1 is linked to Pruritus.