IFNG and neoplasm: Among the 12 included studies, eight reported that FUS increased the number of activated T cells within the treated tumor microenvironment, with upregulation of CD8+ T cells and increased expression of IFN-γ and granzyme B. IFN-γ is closely related to transcription factor regulation, macrophage activation, and expression of antigen processing and presentation molecules, promoting ferroptosis in tumor cells and enhancing the cytotoxic activity of CD8+ T cells (31).