CD4 and neoplasm: treated local tumor: tumor infiltrating lymphocyte, GranzymeB+CD8+Tcell, PD-1-GranzymeB+CD8+Tcell, M1 macrophage▲; spleen: IFN-γ+CD4+Tcell, IL-2+CD8+Tcell, M1 macrophage▲; M2 macrophage fraction▼;