CD4 and neoplasm: treated local tumor: CD45+cell, CD3+T cell, CD4+T cell, CD8+Tcell, IFN-γ+CD8+Tcell, PD-L1+CD45-cell▲; PD-L1+CD45+ cell▼; M2 macrophage fraction▼; distance tumor: CD45+cell, IFN-γ+CD8+Tcell, M1 macrophage fraction▲; MDSCs cell▼; PD-L1+CD45+ cell▼; spleen: CD3+T cell, CD4+T cell, CD8+Tcell, IFN-γ+CD8+Tcell▲