distance tumor: T cell, CD4+T cell, CD8+Tcell, IFNy+CD8+Tcell, F4/80+CD11b+CD45+cell▲ treated local tumor: F4/80+CD11b+CD45+ cell▲ spleen: CD169+macrophage cell▲ serum: CD169+macrophage cell, IFN-α, IFN-β▲ draining lymph node of distance tumor: CD169+cell, SIINFEKL+CD169+cell,SIINFEKL+CD169+MHCII+CD11C+cell,SIINFEKL+F4/80+MHCII+CD11b+cell▲. This evidence concerns the gene CD4 and neoplasm.