IFNG and neoplasm: TNBC is a “hot” tumor (i.e., likely to trigger a strong immune response) because it is an immunoreactive tumor due to the inflamed microenvironment, which is characterized by the presence of cytokines such as IL-1, IL-2, TNFα, and IFNγ produced by CD8+ T cells, NK cells, and M1 macrophages through DC signaling and GM-CSF stimulation (260).