CSF3 and breast cancer: In murine models of BC, proinflammatory cytokines generated by tumor cells, such as interleukin 1 beta (IL-1β), which promotes the expression of IL-17 in γδ T cells, can trigger the polarization of neutrophils towards an N2 phenotype, and expansion of these neutrophils through granulocyte colony-stimulating factor (G-CSF) (73).