Several lines of evidence support this hypothesis: (a) Hubs have high metabolic demands (Bullmore & Sporns, 2012; Drzezga et al., 2011; Tomasi et al., 2013; Vaishnavi et al., 2010); (b) they are especially susceptible to Aβ deposition in AD (Buckner et al., 2009; Bullmore & Sporns, 2012; Drzezga et al., 2011; Myers et al., 2014); and (c) they serve as the spreading centers for tau pathology (Cope et al., 2018; Franzmeier et al., 2020; Frontzkowski et al., 2022). Here, MAPT is linked to Alzheimer disease.