For patients with a confirmed diagnosis of AL amyloidosis, ECG, ECHO, and B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and cardiac troponin T/I (cTnT/I) measurements should be performed at baseline to evaluate cardiac involvement, disease staging, and prognosis. Here, NPPB is linked to AL amyloidosis.