INS and type 1 diabetes mellitus: A 2018 study involved L. lactis secreting human proinsulin and IL-10, also known as AG019, administered orally through a capsule to patients with type 1 diabetes to suppress the autoimmune response that damages insulin-producing cells of the pancreas causing the disease.91 The recombinant proteins were designed to act after colonization of the intestinal tract by the bacteria.