The top 5 most downregulated mouse DEGs during NF1_LV infection were: Immunoglobulin kappa variable 8-28 (immune response), Prolactin receptor (PRL-R) (cytokine-mediated signaling pathway); LIM/homeobox protein Lhx9 (transcription factor), Transglutaminase-5 (peptide cross-linking) and Interleukin-22b (inflammatory response) (Supplementary Table S3). Here, TGM5 is linked to infection.