OTX2 and infection: The top 5 downregulated mouse DEGs during NF45_HV infection were: Immunoglobulin heavy variable V1-7 (innate immune response), Small integral membrane protein 22 (cytoskeleton organization), Transcription factor 21 (morphogenesis), Beta-defensin 11 (innate immune response) and Homeobox protein OTX2 (transcription factor) (Supplementary Table S3).