ADAM22 and epilepsy: In NF1_LV-infected brains, where the infection is still at “early stage”, we observed in a strong downregulation of many nervous system-related genes such as Adam22 (related to adult locomotory behavior), Cacnb4 (linked to adult walking behavior and detection of light stimulus involved in visual perception), Zic1 (related to walking behavior and inner ear morphogenesis), and Gabra1 (mutation of these gene is associated with neurodevelopmental defects and epilepsy) possibly linked to the above mentioned symptoms.