BRAF mutations in codon 600, including c.1799_1800delinsAA (p.Val600Glu-V600E), c.1798_1799delinsAA (p.Val600Lys–V600K), c.1799_1800delinsAC (p.Val600Asp–V600D), and c.1798_1799delinsAG (p.Val600Arg–V600R), are considered to be the most common genetic alteration in CM [3], the prevalence of which reaches 58% in the Ukrainian population [4]. The gene discussed is BRAF; the disease is cutaneous mastocytosis.