TNF and early-onset autosomal dominant Alzheimer disease: Activation of TRPA1 molecules in scalp skin keratinocytes can promote the release of IL-1 α, IL-1β, and PGE2 [45]; Inhibition of TRPA1 in Alzheimer's disease mice can be achieved through NF-κB pathway reduces the expression of IL-1β and IL-6 in mice [28]; Inhibiting TRPA1 can reduce IL-6 and IL-1β and tumor necrosis factor (TNF)-α levels in patients with osteoarthritis [46].