Chronic factors include hereditary (protein C or S deficiency, factor V Leiden, prothrombin G20210A mutation), and acquired thrombophilias (antiphospholipid antibody syndrome, Janus kinase 2 (JAK2) mutation, malignancy, inflammatory bowel disease, Behçet disease, etc.)[3]. The gene discussed is JAK2; the disease is hyperinsulinemic hypoglycemia, familial, 4.