There was marked leukocytosis in all the patients, with a mean value of 71.43 ± 37.93, a range of 35-150 × 109/L, and a p-value of 0.0002 suggestive of marked leukocytosis in positive AML-M2 with RUNX1/RUNX1T1 patients. The gene discussed is RUNX1; the disease is acute myeloid leukemia.