GRM3 and schizophrenia: Pharmacological studies have discovered genes involved in the pathophysiology of schizophrenia (De Jong et al., 2016; Gaspar and Breen, 2017; Rodriguez-Lopez et al., 2020; Ruby et al., 2014), such as GRM3 expression in astrocytic cells, which is required to protect neurons against NMDA induced neurotoxicity (Hikmah et al., 2023).