However, there was no statistically significant association between COVID‐19 severity and anti‐IFNα IgG nor anti‐CD209/CD209L IgM autoantibodies for patients with a similar presentation on admission [OR (95% CI): 3.10 (0.71, 13.47) and 1.39 (0.58, 3.34), respectively]. Here, CD40LG is linked to COVID-19.