The IVW method for genetic prediction revealed that higher levels of fractalkine levels (CX3CL1) (OR = 0.572, 95% CI 0.346–0.946, P = 0.029), latency-associated peptide transforming growth factor beta 1 (TGFB1) (OR = , 95% CI 0.650–0.968, P = 0.023) and Interleukin-10 receptor subunit alpha (IL10RA) (OR = 0.762, 95% CI 0.646–0.899, P = 0.001) were associated with a decreased risk of AMD (Figure 3). The gene discussed is TGFB1; the disease is age-related macular degeneration.