Following FDR correction, the IVW analysis indicated that AMD could result in elevated TNFSF11 (beta = 0.067, 95% CI 0.036–0.097, P < 0.001) and wet AMD may lead to higher levels of CDCP1 (beta = 0.057, 95% CI 0.026–0.087, P < 0.001), IL18R1 (beta = 0.055, 95% CI 0.024–0.085, P < 0.001) and TNFSF11 (beta = 0.054, 95% CI 0.023–0.086, P = 0.001). The gene discussed is IL18R1; the disease is age-related macular degeneration.