The IVW genetic prediction method revealed the presence of elevated levels of Interleukin-15 receptor subunit alpha (IL15RA) (OR = 1.158, 95% CI 1.052–1.275, P = 0.003), Tumor necrosis factor ligand superfamily member 14 (TNFSF14) (OR = 1.202, 95% CI 1.033–1.397, P = 0.017), Interleukin-20 receptor subunit alpha levels (IL20RA) (OR = 1.209, 95% CI 1.004–1.456, P-FDR = 0.045), Interleukin-33 levels (IL33) (OR = 1.324, 95% CI 1.081–1.622, P = 0.007) and Tumor necrosis factor levels (TNF) (OR = 1.230, 95% CI 1.023–1.478, P = 0.028) were associated with an increased risk of AMD. Here, IL15RA is linked to age-related macular degeneration.