Brain abnormalities (especially pachygyria), microcephaly, epilepsy, as well as early onset progressive hearing loss, and cardiovascular and genitourinary abnormalities, may be present.[2, 3] In addition, mutations in ACTG1 cause autosomal dominant, non‐syndromic hereditary hearing loss DFNA20/26 (OMIM 604717), characterized by a post‐lingual‐onset and progressive sensorineural hearing loss (SNHL).[4] It was suggested that BRWS2 represented the severe end of a spectrum of cytoplasmic actin‐associated phenotypes that extend to nonsyndromic hearing loss.[5]. The gene discussed is ACTG1; the disease is hearing loss disorder.