SMR analysis of DNA methylation levels and gout causal gene expression identified seven DNA methylation sites (ALDH3B1: cg18412889, cg23121335, cg25402137; IL2RB: cg25246692, cg11558856; NRBP1: cg15478930; SUMF1: (cg24840601) modifications may regulate ALDH3B1, IL2RB, NRBP1 and SUMF1 expression (Table S11). Here, NRBP1 is linked to gout.