Replication analysis based on MR estimates generated by the IVW method in the Lee Lab cohort, and meta-analysis results (Table S6 and Fig. 2B) indicated that the significant causal association of 8 druggable genes comprising 3 risk genes (ALDH3B1, NRBP1, SUMF1) and 5 protective genes (FCGR2B, IL2RB, RCE1, SLC7A7, THBS3) with gout was robust (Pmeta−analysis < 0.05). This evidence concerns the gene RCE1 and gout.