In addition to TGF‐β, Granulocyte‐Macrophage Colony‐Stimulating Factor (GM‐CSF), Interleukin‐6 (IL‐6), prostaglandin E2 (PGE2), hyaluronan fragments and hypoxia drive the polarization and accumulation of TAN2 neutrophils in HCC.[27, 28, 29] In addition, most C‐X‐C chemokines produced by tumor cells and other cells in the TME possess a strong ability to recruit neutrophils into tumor tissues.[30] In this study, we observed that knockdown of DTX2 led to the inhibition of CXCL2 and CXCL6 in HCC cells. This evidence concerns the gene CXCL2 and neoplasm.