DTX2 and hepatocellular carcinoma: According to published literature on neutrophil function, neutrophils cultured in the supernatant of HCC cells with DTX2 knockdown exhibited increased transcript levels of genes related to innate immune activation.[12, 13, 14] However, genes related to the protumor phenotype of neutrophils (“N2”‐like genes) or immunosuppression and cell mobilization were downregulated (Figure 2J).[1, 15, 16] Flow‐sorted TANs in subcutaneous tumors revealed similar results (Figure S8E, Supporting Information).