During the first weeks of primary HIV infection, the gut-associated lymphoid tissue (GALT) is one of the most severely affected anatomical sites, experiencing very high levels of CD4 + T cell depletion which is not fully restored by ART (Brenchley et al. 2004; Guadalupe et al. 2003; Marchetti et al. 2008). The gene discussed is CD4; the disease is HIV infectious disease.