CFTR and chronic obstructive pulmonary disease: While our study aimed at modelling the behavior of PwCF neutrophils through acquired CFTR dysfunction using inh-172, future studies could explore the effect of cigarette smoke on neutrophil functions in the context of other chronic lung diseases such as chronic obstructive pulmonary disease, given its ability to inhibit CFTR function in the epithelium of people without CFTR mutations52.