This phenomenon has been defined as BCR “stereotypy” and “refers to highly restricted and sometimes identical variable heavy complementarity determining region 3 (VH-CDR3) sequence among different CLL patients” [27] The usage of IGHV in the CLL BCR repertoire is not random since some genes are overrepresented in CLL. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.