THBS4 and colon adenocarcinoma: THBS1, THBS2 and THBS5 proteins exhibited relatively high expression in six cancer types compared to normal samples, except for THBS5 in clear cell renal cell carcinoma (CCRCC), while THBS3 and THBS4 proteins showed lower levels in colon adenocarcinoma (COAD) and HNSC (Fig. 1I).