To provide further insight into the underlying resistance mechanism, the differential gene analysis between oxaliplatin-resistant and sensitive CRC cells was conducted [49] and displayed that the resistant cells exhibited up-regulated genes involved in ECM and collagen pathways, such as COL8A1, COL9A3, and TGFB2 (Fig. 4A and Figure S6A). The gene discussed is COL8A1; the disease is colorectal carcinoma.