In addition to its antiproliferative effects, sirolimus allows the early recovery, within 7–10 days from the switch from a CNI, of HHV‐8 specific T‐cells, both naive and central memory T‐cells, producing interleukin‐2 (IL‐2) only and both IL‐2 and interferon‐gamma, contributing to PT‐KS resolution [4]. This evidence concerns the gene IL2 and Kaposi's sarcoma.