CRP and Splenomegaly: Of note, in HIV‐positive individuals, the definition of an MCD flare/attack includes fever, elevated levels of CRP (higher than 2 gr/dL), which is a surrogate marker of interleukin‐6 (IL‐6), and at least three out of a variety of clinical signs and symptoms, including lymphadenopathies, splenomegaly, pleural effusions, ascites, jaundice, edema, rash, cerebral neurologic symptoms, cough, nasal obstruction, xerostomia, and autoimmune hemolytic anemia [1].