FLI1 and neoplasm: Additionally, there is hypertrophy of irregular nuclei of tumor cells, with uneven chromatin or a coarse granular appearance, and positivity of CD34, CA31, ERG, and Friend leukemia virus integration 1 (FLI-1).5 Surgical resection has been reported to be an effective treatment for HEHE.6 Transcatheter arterial chemoembolization (TACE), liver transplantation, chemotherapy, targeted therapy, and immunotherapy have been used in the treatment of patients with HEHE.5, –7